Waglerin-1-FAM （羧基熒光素標(biāo)記的Waglerin-1）

Waglerin-1 blocks muscle nAChRs

阻斷肌肉乙酰膽堿受體

Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of adult muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the adult nAChR subtypes.

Waglerin-1-FAM技術(shù)資料

氨基酸序列：

FAM-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys⁹-His-Pro-Pro-Cys¹³-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH

二硫鍵： Cys⁹-Cys¹³

長度 (aa)： 22

分子式：C₁₃₃H₁₈₅N₃₇O₃₂S₂

分子量：2878.27 Da

CAS 號：NA

來源：Synthetic

熒光染料：FAM, 5(6)-carboxyfluorescein (λex 492, λem 517)

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