Smartox Biotechnology是*一家專門生產動物毒液多肽毒素，用于細胞離子通道功能研究的生物醫藥公司。多肽毒素在生物制藥領域具有重要的使用價值。

Maurocalcine  

 

Agonist of ryanodine receptors(魚尼丁受體激動劑)

 

 Maurocalcine, a component of the venom of Scorpio maurus palmatus, was discovered by Michel De Waard, co-founder of Smartox.  folds according to an inhibitor cysteine knot. Such as Imperatoxin A,  acts as a high affinity agonist of the type-1 ryanodine receptorexpressed in skeletal muscles with an affinity in the 10 nM range.  induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states.  has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.

 

技術資料

氨基酸序列：

Gly-Asp-Cys³-Leu-Pro-His-Leu-Lys-Leu-Cys¹⁰-Lys-Glu-Asn-Lys-Asp-Cys¹⁶-Cys¹⁷-Ser-Lys-Lys-Cys²¹-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys³²-Arg-OH 

二硫鍵： Cys³-Cys¹⁷, Cys¹⁰-Cys²¹ and Cys¹⁶-Cys³² 

長度 (aa)：33

分子式： C₁₅₆H₂₆₀N₅₆O₄₆S ₆ 

分子量： 3858.8 Da

外觀： White lyophilized solid

可溶性： water and saline buffer

CAS 號：not available

來源：Synthetic 

純度： > 98 %

 

產品信息

07MAU001-00100		0.1mg
07MAU001-00500		0.5mg
07MAU001-01000		1mg