基于斑馬魚的體內(nèi)實(shí)驗(yàn)應(yīng)用有大量的已開發(fā)的人類疾病斑馬魚模型如：
1.代謝綜合癥：肥胖 (內(nèi)臟肥胖)、 血脂異常、脂肪肝、糖耐受失調(diào)
2.人類癌癥細(xì)胞異種移植：腫瘤血管生成、遠(yuǎn)端轉(zhuǎn)移
3.循環(huán)疾病：心力衰竭、藥物誘導(dǎo)的心率失調(diào)
4.中央神經(jīng)系統(tǒng)失調(diào)：耳聾、視力障礙、嗅覺失調(diào)、癲癇、發(fā)育紊亂、睡眠喚醒障礙、肌營(yíng)養(yǎng)不良 (ALS)

下載實(shí)驗(yàn)案例

參考文獻(xiàn)：
1. Zhang, B., et al., Quantitative phenotyping-based in vivo chemical screening

in a zebrafish model of leukemia stem cell xenotransplantation, PLoS One,

2014 Jan 15; 9(1).
2. Umemoto, N., et al., Fluorescent-based methods for gene knockdown and

functional cardiac imaging in zebrafish, Mol Biotechnol, 2013 Oct; 55(2): 131-

42.
3. Kanungo, J., et al., In vivo imaging and quantitative analysis of changes in

axon length using transgenic zebrafish embryos. Neurotoxicol Teratol, 2011

Nov-Dec; 33(6): 618-23.
4. Diekmann, H., et al., Characterization of optic nerve regeneration using

transgenic zebrafish. Front Cell Neurosci, 2015 April 9; 9:118.
5. Huan, H., et al., High-throughput screening for bioactive molecules using

primary cell culture of transgenic zebrafish embryos. Cell Rep, 2012 Sep 27;

2(3):695-704.

歡迎關(guān)注*微信