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目錄:賽默飛世爾科技(中國(guó))有限公司>>一抗>> CD16 Monoclonal Antibody (MEM-168)

CD16 Monoclonal Antibody (MEM-168)
  • CD16 Monoclonal Antibody (MEM-168)
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更新時(shí)間:2025-01-17 08:35:25瀏覽次數(shù):62評(píng)價(jià)

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靶標(biāo)信息CD16encodesareceptorthatrecognizestheFcportionofimmunoglobulinGandisinvolvedintheclearanceofimmunecomplexesfromthecirculation

    靶標(biāo)信息

    CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections. This gene, FCGR3A, shares a high degree of similarity with another nearby gene, FCGR3B, located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been associated with immunodeficiency 20 and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.

     

    CD16 Antibody (MA1-19340) in Flow

    Flow cytometry (surface staining) of lysed and washed porcine peripheral blood with purified anti-CD16 (MEM-168) Monoclonal antibody (Product # MA1-19340) (detection by anti-mouse IgM FITC). Panel A - porcine PBMC stained with Isotype mouse IgM control (PFR-03); Panel B, C, D - three different porcine PMBC samples stained with anti-CD16 (MEM-168). Cells in the granulocyte gate were used for analysis.

    僅用于科研。不用于診斷過程。未經(jīng)明確不得轉(zhuǎn)售。

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