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BPS Bioscience Inc.
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當前位置:BPS Bioscience Inc.>>PARP Assay Kits>> 78441PROTAC® Optimization Kit for PARP1-Cereblon Binding

PROTAC® Optimization Kit for PARP1-Cereblon Binding

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產品型號78441

品       牌BPS Bioscience

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更新時間:2023-11-11 23:59:03瀏覽次數:239次

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●Purchase●DescriptionThePROTAC®OptimizationKitforPARP1-CereblonBindingisdesignedforthetestingandprofilingofPROTACs®directedagainstPARP1andCereblon(CRBN)
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Description

The PROTAC® Optimization Kit for PARP1-Cereblon Binding is designed for the testing and profiling of PROTACs® directed against PARP1 and Cereblon (CRBN). This Kit comes in a convenient AlphaLISA™ format, with the PARP1 Degrader iRucaparib-AP6 (PROTAC®) added as positive control, PARP1 buffer, purified PARP1 and CRBN proteins for 384 reactions. The PARP1 inhibitor Rucaparib is included as a control that blocks PROTAC® binding to PARP1. With this kit, three simple steps are required for the measurement of PROTAC® activity. First, the PROTAC® of interest is incubated with CRBN and PARP1. Next, acceptor beads are added, then donor beads, followed by reading of the Alpha-counts.

Figure 1: Illustration of the assay principle

A PROTAC® of interest or positive control iRucaparib-AP6 (PROTAC®) interacts with both PARP1 and CRBN, bringing them in close proximity. PARP1 contains a GST tag, recognized by the GSH donor bead, while CRBN contains a FLAG tag that binds to the AlphaLISA™ acceptor bead conjugated with an anti-FLAG antibody. Upon excitation of the donor bead, a singlet oxygen is generated by the donor bead. The singlet oxygen excites the acceptor bead and emits light proportionally to the level of interaction. AlphaLISA™ immunoassays are a no-wash alternative to ELISA immunoassays. These assays are robust and ideal for a minimal hands-on approach.

Synonyms
ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, DNA ADP-ribosyltransferase PARP1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, Protein poly-ADP-ribosyltransferase PARP1, PPOL

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