This human monoclonal antibody recognizes human V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA), and neutralizes its interaction with VSIG3 (also called IGSF11). VISTA is also known as B7-H5 or VSIR (GenBank Accession No. NM_022153). VSIG3 is a ligａnd involved in cell adhesion as a VISTA binding partner. This neutralizing antibody has been functionally tested using the “VSIG-3:VISTA [Biotinylated] Inhibitor Screening Assay Kit" (BPS Bioscience #79782).