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Paricalcitol

CAS No. : 131918-61-1

MCE 國際站：Paricalcitol

產品活性：Paricalcitol 是 vitamin D 類似物，是有效的 vitamin D receptor 的激活劑，用于研究繼發性甲狀旁腺功能亢進 (分泌過多的甲狀旁腺激素)，該疾病與慢性腎功能衰竭有關。

研究領域：Vitamin D Related/Nuclear Receptor

作用靶點：VD/VDR

In Vitro: Paricalcitol (3×10^-8 M; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells.

In Vivo: Paricalcitol (300 ng/kg/day) significantly decreases Tau, and prevents LV dysfunction in mice. Paricalcitol reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice.

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