目錄:MedChemExpress LLC>>信號通路>> Tivozanib | 替沃扎尼 | MedChemExpress (MCE)
| CAS | 475108-18-0 | 純度 | 99.37% |
|---|---|---|---|
| 分子量 | 454.86 | 分子式 | C??H??ClN?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-10977 | 應用領域 | 醫(yī)療衛(wèi)生,化工,生物產業(yè),制藥/生物制藥 |
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CAS No. : 475108-18-0
MCE 國際站：Tivozanib
產品活性：Tivozanib (AV-951; KRN951) 是一種有效的、選擇性的、具有口服活性的 VEGFR 酪氨酸激酶 抑制劑，對 VEGFR-1、VEGFR-2、VEGFR-3的 IC50 值分別為 0.21、0.16、0.24 nM。Tivozanib 抑制腫瘤組織中的血管生成和血管通透性，并顯示出抗腫瘤活性。Tivozanib 具有研究轉移性腎細胞癌 (RCC) 的潛力。
研究領域：Protein Tyrosine Kinase/RTK
作用靶點：VEGFR
In Vitro: Tivozanib inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.
In Vivo: Tivozanib (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%.
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