目錄:MedChemExpress LLC>>信號(hào)通路>> Gartisertib | MedChemExpress
| 參考價(jià) | ￥ 4170 |
| 參考價(jià) | ￥ 4170 |
更新時(shí)間：2023-09-28 14:56:13瀏覽次數(shù)：284評(píng)價(jià)
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| CAS | 1613191-99-3 | 純度 | 99.76% |
|---|---|---|---|
| 分子量 | 541.55 | 分子式 | C??H??F?N?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號(hào) | HY-136270 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥/生物制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 1613191-99-3
MCE 國(guó)際站：Gartisertib
產(chǎn)品活性：Gartisertib (VX-803) 是一種 ATP 競(jìng)爭(zhēng)性的，具有口服活性的，選擇性的 ATR 抑制劑，Ki<150 pM。Gartisertib 抑制 ATR 驅(qū)動(dòng)的磷酸化檢查點(diǎn)激酶-1 (Chk1) 磷酸化, IC50值為 8 nM。具有抗腫瘤活性。
研究領(lǐng)域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR
作用靶點(diǎn)：ATM/ATR
In Vivo: In monotherapy efficacy studies Gartisertib shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). In combination with PARP inhibitors, tumor regression could be observed in triple-negative breast cancer xenograft models.
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