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O-304

CAS No. : 1261289-04-6

產品活性：O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .

研究領域：Epigenetics  |  PI3K/Akt/mTOR

作用靶點：AMPK

In Vivo: O-304 increases glucose uptake in skeletal muscle, reduced β cell stress, and promoted β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin.

相關產品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Pain-Related Compound Library  |  ZLN024  |  YLF-466D  |  Nepodin  |  AMPK activator 9  |  Metformin-d₆ (hydrochloride)  |  AMPK-IN-3  |  HTH-01-015  |  AMARA peptide TFA  |  LRRK2/NUAK1/TYK2-IN-1  |  AMPK-IN-1  |  AICAR  |  Metformin  |  BC1618  |  BAY-3827  |  Chamaejasmine  |  PF-06409577  |  Etilefrine  |  IM156  |  Narazaciclib  |  Flufenamic acid-d₄  |  PF-739  |  RSVA405  |  MARK4 inhibitor 1  |  Phenformin hydrochloride  |  MARK-IN-2  |  Danthron  |  Galegine hydrochloride  |  Dorsomorphin  |  Gomisin J  |  Palmitelaidic Acid

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