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ADU-S100

CAS No. : 1638241-89-0

產品活性：ADU-S100 (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.

研究領域：Immunology/Inflammation

作用靶點：STING

In Vitro: ADU-S100 is unstable in its free base form. ADU-S100 ammonium salt (HY-12885B) improves both stability and lipophilicity, promoting significantly increased STING signaling as compared to endogenous and pathogen-derived cyclic dinucleotides (CDNs).
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage CDN derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING^REF and hSTING^Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.

In Vivo: ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8⁺ T cell responses, and improves long-term survival to 50%.

相關產品：Cyclic-di-GMP disodium  |  Dazostinag disodium  |  STING-IN-2  |  CL845-PAB-Ala-Val-C5-MC  |  STING agonist-13  |  STING agonist-26  |  ADU-S100 ammonium salt  |  cGAMP  |  Ulevostinag  |  STING ligand-1  |  STING agonist-28  |  C-178  |  C-176  |  STING agonist-20  |  2',3'-cGAMP sodium  |  PROTAC STING Degrader-1  |  CL656  |  H-151  |  STING agonist-12  |  JAK-IN-23  |  BSP16  |  STING agonist-8  |  STING modulator-5  |  CCCP  |  IACS-8803  |  STING agonist-11  |  STING agonist-22  |  STING agonist-24

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