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KDOAM-25 citrate

CAS No. : 2448475-08-7

產品活性：KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC₅₀s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.

研究領域：Epigenetics

作用靶點：Histone Demethylase

In Vitro: KDOAM-25 citrate inhibits most potently KDM5B with an IC₅₀ of ～50 μM and the other KDM5 family members at concentrations above 100 μM. KDOAM-25 citrate shows no cellular activity on any of the other tested JmjC family members.
KDOAM-25 citrate is able to reduce the viability of MM1S cells with an IC₅₀ of ～30 μM after a delay of 5-7 days.
KDOAM-25 citrate treatment results in a G1 cell-cycle arrest with an increased proportion of MM1S in G1 and a decrease of the proportion of cells in G2 without an increase in the proportion of cells in the apoptotic sub-G1 phase.
KDOAM-25 citrate (50 μM) increases with approximately twice as much H3K4me3 in in multiple myeloma cells.

相關產品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Transcription Factor-Targeted Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  GSK2879552 dihydrochloride  |  KDM2B-IN-3  |  KDM4-IN-2  |  LSD1/ER-IN-1  |  GSK-J4 hydrochloride  |  Bomedemstat hydrochloride  |  LSD1-IN-18  |  KDM4-IN-4  |  (1S,2R)-Tranylcypromine hydrochloride  |  Pulrodemstat benzenesulfonate  |  GSK-J1 lithium salt  |  CPI-4203  |  JQKD82  |  Corin  |  Tranylcypromine hemisulfate  |  KDM2B-IN-4  |  LSD1-IN-14  |  Helenalin acetate  |  KDM2B-IN-2  |  Seclidemstat  |  KDM5-IN-1  |  GSK-LSD1 dihydrochloride  |  LSD1-IN-21  |  KDM4-IN-3  |  LSD1/2-IN-4  |  NCDM-32B  |  Eicosapentaenoic Acid  |  LSD1-IN-15

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