MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Tiron

CAS No. : 149-45-1

產品活性：Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals.

研究領域：Others  |  Apoptosis

作用靶點：Biochemical Assay Reagents  |  Apoptosis

In Vitro: Tiron (10 mM) protects Chinese hamster V79 cells against H₂O₂-induced cytotoxicity.
Tiron (0-20 mM) protects supercoiled DNA from metal-mediated superoxide-dependent strand breaks.
Tiron (50 nM-200 nM, 48 h) inhibits HG-induced neonatal rat cardiomyocytes apoptosis.
Tiron (50 nM-200 nM, 48 h) reduces intracellular osteopontin in neonatal rat cardiomyocytes.
Tiron (0.2 mM, 2 h) inhibits UVB-induced up-regulation of MMP-1 and MMP-3 in HDFs.
Tiron (0.7 mM, 48 h) increases the percentage of PT4 cells in both the S and G2/M phases.

In Vivo: Tiron (200 mg/kg, oral gavage) ameliorates oxidative stress and inflammation in a murine model of airway remodeling.
Tiron (300 mg/kg, i.p., daily for two weeks) alleviated apoptosis of the left ventricular cardiomyocytes in STZ-induced diabetic mice.

相關產品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Oxygen Sensing Compound Library  |  Orally Active Compound Library  |  SY-5609  |  BRD4 Inhibitor-18  |  Levoglucosenone  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  AAPK-25  |  Dutasteride-¹³C₆  |  Maltotriose hydrate  |  Oleic acid-¹³C  |  Methyl β-D-Arabinopyranoside  |  Methyl 12-aminododecanoate hydrochloride  |  Methyl undec-10-enoate  |  DDMAB  |  Abacavir sulfate  |  Meloxicam-d₃-1  |  Thailanstatin D  |  Allyl heptanoate  |  SB-218078  |  Toyocamycin  |  Sorafenib-d₄  |  Octyl α-D-glucopyranoside  |  Nonyl-β-D-1-thiomaltoside  |  trans-2-Undecenal  |  Homobrassinolide  |  Busulfan  |  PTC-028  |  Dinaciclib  |  Orange G  |  CR-1-31-B  |  142I5  |  Farudodstat

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
•   設有專業的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業團隊跟蹤新的制藥及生命科學研究進展，為您提供*新的活性化合物；
•   與世界各大制藥公司及*科研機構建立了長期的合作。