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Cariporide

CAS No. : 159138-80-4

產品活性：Cariporide (HOE-642) is a selective Na⁺/H⁺ exchange inhibitor.

研究領域：Membrane Transporter/Ion Channel

作用靶點：Na+/H+ Exchanger (NHE)

In Vitro: Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na⁺ and Ca²⁺ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H²⁺O²⁺. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca²⁺ in cardiac myocytes through inhibition of Na⁺/H⁺ exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).

In Vivo: Intravenous administration of cariporide significantly decreases brain Na⁺ uptake and reduces cerebral edema, brain swelling, and infarct volume.

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