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Mogamulizumab

CAS No. : 1159266-37-1

產品活性：Mogamulizumab (KW-0761) is a defucosylated humanized recombinant anti-CCR4 monoclonal antibody (MAb). Mogamulizumab can eliminate tumor cells by antibody-dependent cellular cytotoxicity (ADCC). Mogamulizumab can be used in the research of cancers, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL).

研究領域：GPCR/G Protein  |  Immunology/Inflammation

作用靶點：CCR

In Vitro: Mogamulizumab (10 μg/mL, 24 h) induces ADCC activity against CCR4-positive cell lines (SNT8, SNT16, SNK6, and KAI3) in the presence of PBMCs.
Mogamulizumab (10 μg/mL, 3 days) reduces the human T-lymphotropic virus type 1 (HTLV-1) proviral load and inhibits spontaneous proliferation in PBMCs from patients with HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Mogamulizumab (1 μg/mL, 5 days) eliminates the CD4⁺CCR4⁺ T cells in cultured PBMCs from patients with HAM/TSP.

In Vivo: Mogamulizumab (1 mg/kg, i.p., twice per week for 4 weeks) together with PBMC transplantation inhibits the growth of EBV-positive NK-cell lymphomas in a murine xenograft model.
Mogamulizumab (0.1 mg/kg, i.v., every other day) together with canine PBMCs (every fourth day)), inhibits tumor growth in canine bladder cancer-engrafted mouse model.
Mogamulizumab (0.01-1 mg/kg, i.v.) reduces circulating CD4⁺CCR4⁺ T cells, with no adverse effect in dogs.

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