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產(chǎn)品名稱(chēng)：IPEC-J2 豬小腸上皮細(xì)胞、IPEC-J2 豬小腸上皮細(xì)胞、IPEC-J2 豬小腸上皮細(xì)胞、IPEC-J2 豬小腸上皮細(xì)胞；

豬正常腸上皮細(xì)胞IPEC-J2

種屬	豬
別稱(chēng)	IPECJ2; Intestinal Porcine Epithelial Cell line-J2
組織來(lái)源	腸（空腸）
疾病	正常
傳代比例/細(xì)胞消化	1:2傳代，消化1-3分鐘
培養(yǎng)基配置	DMEM培養(yǎng)基；10%胎牛血清；1%雙抗
簡(jiǎn)介	該細(xì)胞從一只新生的未感染豬空腸分離的正常腸上皮細(xì)胞中建立，經(jīng)歷一個(gè)自發(fā)的分化過(guò)程，在1-2周內(nèi)形成具有低或高跨上皮電阻（TEER）的極化單層，這取決于加入培養(yǎng)基的血清類(lèi)型。
形態(tài)	上皮細(xì)胞樣
生長(zhǎng)特征	貼壁生長(zhǎng)
倍增時(shí)間	每周 2 至 3 次
培養(yǎng)條件	氣相：空氣，95% ；二氧化碳，5%。溫度：37攝氏度，培養(yǎng)箱濕度為70%-80%。
凍存條件	凍存液：90%FBS ，DMSO 10%, 或使用非程序凍存液：貨號(hào)JY-H040
保藏機(jī)構(gòu)	DSMZ; ACC-701
產(chǎn)品使用	于科學(xué)研究，不可作為動(dòng)物或人類(lèi)疾病的治療產(chǎn)品使用。

The aim of this study is to determine whether the pretreatment CD8+PD-1+ to CD4+PD-1+ (PERLS) ratio is an independent risk prognostic factor of advanced melanoma patients. We retrospectively analyzed the efficacy and flow cytometry data from advanced melanoma patients who received PD-1 inhibitor as monotherapy between January 1, 2018 and January 26, 2022. Fifty-nine patients were enrolled, the PERLS cutoff was 1.125. PERLS did not correlate with clinical characteristics but were significantly associated with baseline CD8+, CD4+, and CD8+PD-1+ T cells. The mean overall survival and the progression-free survival were 45.8 and 17.1?months for the low PERLS group (n?=?39), compared with 29.9 (P?=?0.001) and 9.7 (P?=?0.003) months for the high PERLS group (n?=?20), respectively. Pretreatment PERLS might contribute to selecting patients before receiving anti-PD-1 therapy.