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Clarke, A. J., and Simon, A. K. (2019). Autophagy in the renewal, di?erentiation and homeostasis of immune cells. Nat. Rev. Immunol. 19, 170–183 Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with a high fatality rate. The clinical diagnosis criteria mainly rely on white blood cell (WBC) and platelet (PLT), which, however, are of limited usage in identifying atypical SFTS. A multicenter study was performed in two hospitals from 2011 to 2023. SFTS patients were categorized as atypical or typical based on the clinical diagnosis criteria.