| 概述 |
|
| 別名 | Inducible T-cell costimulator; AILIM |
| 宿主 | Rabbit |
| 反應種屬 | Human |
| 應用 | IHC-P: 1:500 |
| 性能 |
|
| 形式 | Liquid |
| 濃度 | 0.5 mg/ml |
| 純化方法 | Protein A affinity column |
| 類型 | Monoclonal Antibody |
| 克隆號 | R104 |
| 儲存/保存方法 | Store at -20℃ for one year. |
| 存儲溶液 | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| 靶標 |
|
| 背景說明 | Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728]. |
| 細胞定位 | Cell Membrane, Secreted |
| UniProt | Q9Y6W8 |
| 實驗結果圖 |
|
| IHC shows positive staining in paraffin-embedded human thymus. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol. |
| IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol. |
| IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol. |
| Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol. |
| 溫馨提示：本產品僅作科研實驗使用，不支持臨床等研究 |
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