僅用于工業應用或科學研究，不可用于人類或動物的臨床診斷或治療，非藥用. Ponsegromab （PF 06946860） is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers