非布司他雜質非布索坦雜質申報

時間：2017/3/2閱讀：1189

非布司他適應癥及作用機理：非布司他主要成份為非布佐司他，其化學名為2-[(3-氰基-4-異丁氧基)苯基]-4-甲基-5-噻唑羧酸。為黃嘌呤氧化酶（XO）抑制劑，適用于具有痛風癥狀的高尿酸血癥的長期治療。非布佐司他是黃嘌呤氧化酶抑制劑，通過減少血清尿酸達到療效。本品在治療濃度下不會抑制嘌呤和嘧啶的合成及代謝過程中的其他酶。

深圳遠揚化學技術有限公司提供的非布司他雜質純度高，來源正規，*非布司他新藥申報的要求，隨貨提供COA證書，氫譜，質譜及HPLC，。（請點擊本頁標題下方“進入該公司展臺” 查看我司信息）。

Febuxostat	2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 1	ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 2	ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 3	ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 4	2-(3-carbamoyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 5	ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 6	(E)-ethyl 2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 7	(E)-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 8	2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 9	2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 10	2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid 1-oxide
Febuxostat Impurity 11	2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 12	4-isobutoxybenzene-1,3-bis(carbothioamide)
Febuxostat Impurity 13	dimethyl 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylate)
Febuxostat Impurity 14	2-isobutoxy-5-(4-methylthiazol-2-yl)benzonitrile
Febuxostat Impurity 15	2-(4-butoxy-3-cyanophenyl)thiazole-5-carboxylic acid
Febuxostat Impurity 16	2-(4-(sec-butoxy)-3-cyanophenyl)thiazole-5-carboxylic acid
Febuxostat Impurity 17	2-(3-cyano-4-propoxyphenyl)thiazole-5-carboxylic acid
Febuxostat Impurity 18	ethyl 2-(4-hydroxy-3-vinylphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 19	ethyl 2-(2-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 20	2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylic acid)
Febuxostat Impurity 21	diethyl 2,2'-(4-isobutoxy-1,3-phenylene)bis(4-methylthiazole-5-carboxylate)
Febuxostat Impurity 22	ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 23	2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 24	2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 25	2-(3-carboxy-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 26	2-(3-carbamoyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 27	2-(4-butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 28	2-(4-(sec-butoxy)-3-cyanophenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 29	2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 30	2-(3-cyano-4-ethoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 31	(E)-ethyl 2-(4-hydroxy-3-((hydroxyimino)methyl)phenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 32	ethyl 2-(3-formyl-2-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 33	2-(3-cyano-4-isopropoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 34	isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 35	methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 36	2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
Febuxostat Impurity 37	ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 38	2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

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