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OsteoGen3D灌注生物反應器系統（體外三維骨構造體接種細胞培養基灌注培養系統）
OsteoGen生物反應器通過圓筒支架灌注接種細胞。應用范圍包括細胞功能研究、組織工程構建物生長和發育、藥物和再生醫學測試。目前研究人員正在利用這些系統在廣泛的范圍內開展研究領域，包括：
- 骨髓干細胞表型研究
- 骨髓基質干細胞礦物質沉積
OsteoGen提供了一個生理支持系統，改善了3D環境中的細胞生長和代謝條件。系統通過反饋控制再現了生理刺激參數。靈活的硬件和計算機控制系統允許各種各樣的自動化實驗步驟，具有不同程度的復雜性（壓力幅度和頻率），并可以容納10 mm長度的支架。OsteoGen系統可容納多達12個樣品，樣品之間相互獨立，樣品同時經受灌注循環。灌注泵可以提供低至0.06 mL/min的流量。
應用領域：礦化研究和骨組織工程。
OsteoGen: Perfusion Bioreactor Systems
BISS's OsteoGen bioreactors impart perfusion through cell seeded cylindrical scaffolds. Applications include investigating cell function, modulating the growth and development of engineered tissues, or acting as a test bed for drug and regenerative medicine technologies. Researchers are currently utilizing these systems in a wide range of research areas including:
- Bone stem cell phenotype research
- Mineral deposition of marrowstromal cells
1O OsteoGen
The 1O system has been designed as a single sample bioreactor system that is able to support a wide range of cell and tissue growth experiments. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. Optional features such as: transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accommodate the research application.
12O OsteoGen
The 12O system has been designed as a single sample multi-chamber bioreactor system that is able to support a wide range of cell and tissue growth experiments via user defined stimulation protocols. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. A custom manifold integrates up to 12 chambers with individual flow loops. Optional features such as; transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accommodate the research application.
BONE
Key: S=Standard, A=Available, - = not available
| CHAMBERS | 1O | 12O |
|---|---|---|
| Individual growth chamber | S | S |
| 12 parallel growth chambers | - | A |
| Max construct size: 6 mm diameter by 10 mm long | S | S |
| STIMULATION | ||
|---|---|---|
| Pulsatile fluid flow stimulator | A | A |
| CONTROLS | ||
|---|---|---|
| Controller software, computer, and monitor | - | - |
| Power supplies and cabling | - | - |
| Mean flow control | A | A |
| Dynamic flow control | - | - |
| TISSUE MONITORING | ||
|---|---|---|
| Non-contact flow sensors | A | A |
| Catheter pressure transducers | A | A |
| ACCESSORIES | ||
|---|---|---|
| Media reservoir | S | S |
| Incubator | A | A |
| BENEFITS | ||
|---|---|---|
| All-autoclavable components | S | S |
| Excellent sample access | S | S |
| Medium change without opening chamber via luer fittings | S | S |
| Increased sterility with fast and clean sample change and access | S | S |
| Lightweight design for easy handling | S | S |
| Easily cleaned surface finishes | S | S |
| Compact design for fit in standard incubators | S | S |
| 100% satisfaction guaranteed warranty | S | S |
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