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- 產品描述： Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects
- 靶點： 5-HT1A Receptor:5.74 (pKi);5-HT2A Receptor:7.54 (pKi);5-HT2C Receptor:5.55 (pKi);D2 Receptor:7.25 (pKi);5-HT1A Receptor:4.77 (pEC50);D2 Receptor:6.33 (pIC50)
- 體內研究： Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination
- 參考文獻：
1. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. 2. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.
- 溶解度： Soluble in DMSO、H2O、Ethanol
- 保存條件： 2-8℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.607 ml 13.037 ml 26.075 ml 5 mM 0.521 ml 2.607 ml 5.215 ml 10 mM 0.261 ml 1.304 ml 2.607 ml 50 mM 0.052 ml 0.261 ml 0.521 ml
- 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的性，僅供客戶參考交流研究之用。
