IPA-3  42521-82-4

IPA-3
分子式：C20H14O2S2   分子量：350.45
 
產品描述
IPA-3是選擇性，非ATP競爭性Pak1抑制劑，IC50為2.5 μM, 對II組PAKs(PAKs 4-6)沒有抑制作用。
靶點
           
IC50
           
體外研究
IPA 3 is a selective cell permeable Pak1 (group I p21-activated kinase) inhibitor which functions by inhibiting activators from binding to the active sites on the enzyme. Pak1 contain autoinhibitory regions that suppress the catalytic activity of its kinase domain, which are removed once activators have bound to the protein. In addition, IPA 3 does not inhibit Pak1 if activators are already bound to the enzyme. Furthermore, IPA 3 can also inhibit the activity of Pak1 isomers that are structurally similar by autoinhibition.
體內研究
 
溶解性
DMSO 70 mg/mL，水 <1 mg/mL，乙醇 7 mg/mL
穩定性
2年 -20°C粉狀，6月-80°C溶于DMSO