NDGA (Nordihydroguaiaretic acid) 500-38-9

 NDGA (Nordihydroguaiaretic acid)
分子式：C18H22O4   分子量：302.36
 
產(chǎn)品描述
Nordihydroguaiaretic acid (NDGA)是一種天然苯酚化合物，由灌木Larrea divaricata的雜酚油中分離得到，在體外和體內(nèi)都具有抗癌活性。它的類似物已經(jīng)進(jìn)行臨床開發(fā)，用于治療難治性的實體腫瘤
靶點
           
IC50
           
體外研究
NDGA may also direct target mTORC1 complex because NDGA suppressed amino acids- and insulin-stimulated mTORC1 and acted like rapamycin to disrupt mTOR-Raptor interaction. NDGA increased PPARα promoter activity in AML12 hepatocytes and also prevented the fatty acid suppression of PPARα expression. In contrast, PPARα siRNA abrogated the stimulatory effect of NDGA on fatty acidcatabolism
體內(nèi)研究
NDGA was able to induce Nrf2 translocation in vivo in kidneys of rats submitted to both U-NX and I/R injury and to protect against renal histological damage and apoptosis . Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan;neither NDGA (p=0.12) nor aspirin (p=0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylicacid metabolite suggest that the observed lack of effects of NDGA or aspirin on life span in females could be related to gender differences in drug disposition or metabolism
溶解性
DMSO 微溶，乙醇 微溶，水 不溶
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO