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S81225

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上海源葉生物科技有限公司是一家專門從事生物技術相關產品研發和銷售的綜合性生命科學公司,在全體員工的不懈努力和廣大客戶的大力支持下,公司迅速成長為一家擁有生物試劑部、實驗及醫用耗材部、生命科學儀器部以及技術服務部等部門的高新技術企業。





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  • 提示:詳情請下載說明書。
  • 產品描述: U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor
  • 靶點: MEK2:60 nM (IC50);MEK1:70 nM (IC50)
  • 體內研究: Mice are treated daily with U0126-EtOH (U0126; i.p., 10.5 mg/kg). In control experiment, tumor sizes are constant or slightly increase all over the kinetic. At the opposite, in all U0126-EtOH experiments, engraftment and early tumor growth are significantly decreased. Furthermore, a 60-70% reduction in the volume of tumors treated with U0126-EtOH is obtained 9 days after injection and thereafter. Rats are subjected to 120 minutes transient middle cerebral artery occlusion (tMCAO) and thereafter treated with the U0126-EtOH (U0126; i.p., 30 mg/kg) at 0 and 24 hours of reperfusion. After treatment with U0126-EtOH, the vasoconstriction to S6c is markedly reduced
  • 參考文獻:
    1. Favata MF, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32. 2. Droebner K, et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011, 92(2), 195-203. 3. Bessard A, et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11;27(40):5315-25. 4. Ahnstedt H, et al. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar;35(3):454-60.
  • 溶解度: DMSO  :  50  mg/mL  (117.22  mM;  Need  ultrasonic)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.344 ml 11.722 ml 23.443 ml
    5 mM 0.469 ml 2.344 ml 4.689 ml
    10 mM 0.234 ml 1.172 ml 2.344 ml
    50 mM 0.047 ml 0.234 ml 0.469 ml
  • 注意:部分產品我司僅能提供部分信息,我司不保證所提供信息的性,僅供客戶參考交流研究之用。


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