類器官Hydrocortisone
- 公司名稱 普邁精醫科技（北京）有限公司
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| 供貨周期 | 現貨 |
|---|
類器官Hydrocortisone類器官（Organoids）是指將成體干細胞或多能干細胞在體外三維培養形成的具有一定空間結構的組織類似物。類器官在組織結構、細胞類型、自我更新能力和功能等方面與來源組織高度一致，從而在發育生物學、疾病造模、精準醫學、藥物研發、基因和細胞療法、感染和免疫以及再生醫學等生物醫學的多個領域展現出*的優勢。
產品介紹
DESCRIPTION
| Background | Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1]. | ||
| Alias | Cortisol；氫化可的松；17-羥基皮質 (甾) 酮；皮質甾醇；氫化皮質素 | ||
| M. W t | 362.46 | ||
| Formula | C21H30O5 | ||
| CAS No | 50-23-7 | ||
| Storage | Powder | -20 °C | 3 years |
| In solvent | -80 °C | 6 months | |
| -20 °C | 1 month | ||
| Solubility | DMSO H2O : < 0.1 mg/mL | ≥ 31 mg/mL(85.53 mM) | |
| Ethanol | 23 mg/mL(63.46 mM) | ||
| H2O | < 0.1 mg/mL(insoluble) | ||
BIOLOGICAL ALTIVITY
In Vitro
Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].
In Vivo
| NCT00621985 | Boston Children′s Hospital | Adrenal Hyperplasia, Congenital | Phase 2 |
| NCT03910088 | Cairo University | Post-Dural Puncture Headache | Phase 4 |
| NCT00657306 | University of Turin, Italy | Cirrhosis With Ascites | Phase 2 |
類器官Hydrocortisone
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